Who issues Melio’s single-use virtual cards? Updated November 23, 2022 14:44 Melio’s single-use virtual cards are MasterCards issued by JPMorgan Chase & Co. Was this article helpful? Yes No 0 out of 0 found this helpful Have more questions? Submit a request Related articles How much does it cost to use a single-use virtual card? What is the difference between single-use virtual cards and other delivery methods? How do I process a single-use virtual card? Why has my vendor’s delivery method changed to single-use virtual card? Why was my payment denied?